KRISFED Syrup Ref.[115646] Active ingredients: Chlorphenamine

Source: Registered Drug Product Database (NG)  Publisher: Krishat Pharma Industries Limited KM 15, Lagos-Ibadan Expressway, Ibadan, Oyo State, NIGERIA, Email: info@krishatpharma.com

4.1. Therapeutic indications

Krisfed Syrup is indicated for symptomatic control of all allergic conditions responsive to antihistamines, including hay fever, vasomotor rhinitis, urticaria, angioneurotic oedema, food allergy, drug and serum reactions, insect bites.

4.2. Posology and method of administration

Oral administration only.

Do not exceed the stated dose or frequency of dosing.

The minimum interval between the doses should be 4 hours.

Do not use continuously for more than two weeks without consulting a doctor.

Adults and children 12 years and over

10 ml (4 mg) every 4 to 6 hourly.

Maximum daily dose: 60 ml (24 mg) in any 24 hours.

Elderly

The elderly are more likely to experience neurological anticholinergic effects. Consideration should be given to using a lower daily dose (e.g. a maximum of 12 mg in any 24 hours).

Children aged 6-12 years

5 ml (2 mg) every 4 to 6 hourly.

Maximum daily dose: 30 ml (12 mg) in any 24 hours.

Children aged 2-6 years

2.5 ml (1 mg) every 4 to 6 hourly.

Maximum daily dose: 15 ml (6 mg) in any 24 hours.

Children aged 1-2 years

2.5 ml (1 mg) twice daily.

Maximum daily dose: 5 ml (2 mg) in any 24 hours.

Not recommended for children below 1 year.

Populations

Patients with renal or hepatic impairment should seek doctor’s advice prior to taking this medicine.

4.9. Overdose

Symptoms and signs

The estimated lethal dose of chlorphenamine is 25 to 50 mg/kg body weight. Symptoms and signs include sedation, paradoxical excitation of the CNS, toxic psychosis, convulsions, apnoea, anticholinergic effects, dystonic reactions and cardiovascular collapse including arrhythmias.

Treatment

Management should be as clinically indicated or as recommended by the national poisons centres where available. Symptomatic and supportive measures should be provided with special attention to cardiac, respiratory, renal and hepatic functions and fluid and electrolyte balance. If overdosage is by the oral route, treatment with activated charcoal should be considered provided there are no contraindications for use and the overdose has been taken recently (treatment is most effective if given within an hour of ingestion). Treat hypotension and arrhythmias vigorously. CNS convulsions may be treated with i.v. diazepam. Haemoperfusion may be used in severe cases.

6.3. Shelf life

36 months.

6.4. Special precautions for storage

Protect from light. Store below 30°C.

6.5. Nature and contents of container

Plastic bottle containing 100 ml of Krisfed Syrup.

6.6. Special precautions for disposal and other handling

None stated.

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