LARYKUL FORTE Hard gelatin capsule Ref.[115676] Active ingredients: Folic acid Pregabalin Pyridoxine Thioctic acid Vitamin B12

• Chronic conditions such as diabetes, thyroid dysfunction may be affected by alpha-lipoic acid. Please monitor such individuals closely if supplementation is needed.
• Protect medicines from moisture & light. keep all medicines out of reach of children.

Excessive alcohol consumption, antibiotics, anti-acne drugs, anti-retroviral, anti-gout drugs, anti-hypertensive, anti-tuberculosis drugs, anti-ulcer drugs, biguanides (oral anti-diabetic drugs), histamine (H₂) blocking drugs, oral contraceptives, proton pump inhibitors, sulfonamides (anti-infectives), tetracyclines(anti-infectives) and epilepsy (seizure) medications can deplete vitamin B₁₂ levels.

Thiamine is inactivated by 5-fluorouracil as the latter competitively inhibits the phosphorylation of thiamine to thiamine pyrophosphate.

Loop diuretics, e.g. furosemide that inhibit tubular reabsorption may cause increased excretion of thiamine in long-term therapy and, thus, lowering of the thiamine level.

If taken simultaneously with L-dopa, vitamin B₆ can lessen the dopa effect.

The simultaneous administration of pyridoxine antagonists (e.g. isoniazide (INH), hydralazine, D-penicillamine or cycloserine) may increase the vitamin B₆ requirement.

Beverages containing sulphite (e.g. wine) enhance thiamine degradation.

Alpha-lipoic acid may have additive affects when administered with anti-diabetic drugs. Alpha-lipoic acid may also increase the efficiency of chemotherapeutic drugs.

Since pregabalin is predominantly excreted unchanged in the urine, undergoes negligible metabolism in humans (<2% of a dose recovered in urine as metabolites), does not inhibit drug metabolism in vitro, and is not bound to plasma proteins, it is unlikely to produce, or be subject to, pharmacokinetic interactions.

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Pregabalin may have minor or moderate influence on the ability to drive and use machines. Pregabalin may cause dizziness and somnolence and therefore may influence the ability to drive or use machines. Patients are advised not to drive, operate complex machinery or engage in other potentially hazardous activities until it is known whether this medicinal product affects their ability to perform these activities.

1) Nausea or stomach upset, along with over-stimulation, fatigue, and insomnia.

2) High doses of alpha lipoic acid could also potentially lower blood sugar. This is often beneficial to patients who have diabetes, but it requires close monitoring of blood sugar levels. Dizziness, Drowsiness, Dry mouth, Constipation.

None stated.