LIQUIVISC Eye gel Ref.[49990] Active ingredients: Carbomer

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2021  Publisher: Laboratoires Thea, 12 rue Louis Blériot, Z.I.du Brézet, 63017 Clermont-Ferrand Cedex 2, France

5.1. Pharmacodynamic properties

TEAR SUBSTITUTE

(S: Sensory organ (eye))

  • Fluid eye gel based on a high molecular weight hydrophilic polymer (carbomer 974P).
  • Due to its physical properties, this gel forms a transparent lubricating and wetting film on the surface of the eye, temporarily compensating for tear insufficiency.
  • Its pH (7.3) and osmolality are similar to those of the normal tear film.
  • Its viscosity (700 mPas) is greater than that of artificial tears, allowing less frequent administration.

5.2. Pharmacokinetic properties

Because of the relatively large size of the carbomer molecule, penetration through the cornea is unlikely.

The persistence time of the gel on the eye surface is about 30 minutes.

5.3. Preclinical safety data

Data from subacute toxicity and local tolerance studies do not show any relevant findings.

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