MAALOX Oral suspension Ref.[50870] Active ingredients: Aluminium hydroxide Magnesium hydroxide

Source: Health Products Regulatory Authority (IE)  Revision Year: 2021  Publisher: Opella Healthcare France SAS T/A Sanofi, 82 Avenue Raspail, 94250 Gentilly, France

5.1. Pharmacodynamic properties

Maalox is a balanced mixture of two antacids: aluminium hydroxide is a slow acting antacid and magnesium hydroxide is a fast acting one. The two are frequently combined in antacid mixtures. Aluminium hydroxide on its own is astringent and may cause constipation. This effect is balanced by the effect of magnesium hydroxide, which, in common with other magnesium salts, may cause diarrhoea.

5.2. Pharmacokinetic properties

The absorption of aluminium and magnesium from antacids is small. Aluminium hydroxide is slowly converted to aluminium chloride in the stomach. Some absorption of soluble aluminium salts occurs in the gastro intestinal tract with urinary excretion. Any absorbed magnesium is likewise excreted in the urine.

5.3. Preclinical safety data

Not relevant.

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