Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2021 Publisher: hameln pharma limited, Nexus, Gloucester Business Park, Gloucester, GL3 4AG, United Kingdom
Neostigmine inhibits cholinesterase activity and prolongs and intensifies the muscarinic and nicotinic effects of acetylcholine. The anticholinesterase actions of Neostigmine are reversible. It is used mainly for its action on skeletal muscle and less frequently to increase the activity of smooth muscle. Neostigmine is used in the treatment of Myasthenia Gravis.
Neostigmine is a quaternary ammonium compound and is poorly absorbed from the gastrointestinal tract. Following parenteral administration as the methylsulfate, neostigmine is metabolised partly by hydrolysis of the ester linkage and is excreted in the urine both as unchanged drug and as metabolites. The half-life of neostigmine is only one to two hours.
No further information other than that which is included in the Summary of Product Characteristics.
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