Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2018 Publisher: Baxter Healthcare Ltd., Caxton Way, Thetford, Norfolk IP24 3SE, United Kingdom
Pharmacotherapeutic group: "Other IV Solution Additives"
ATC code: B05XX
Sodium Chloride 0.9% intravenous infusion is an isotonic solution, with an approximate osmolarity of 308 mOsm/l.
The pharmacodynamic properties of the solution are those of the sodium and chloride ions in maintaining the fluid and electrolyte balance. Ions, such as sodium, circulate through the cell membrane, using various mechanisms of transport, among which is the sodium pump (Na-K-ATPase). Sodium plays an important role in neurotransmission and cardiac electrophysiology, and also in its renal metabolism.
Sodium is predominantly excreted by the kidney, but there is extensive renal reabsorption.
Small amounts of sodium are lost in the faeces and sweat.
The safety of sodium chloride in animals is not relevant in view of its presence as a normal component in animal and human plasma.
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