SYRISAL Oral solution Ref.[49958] Active ingredients: Sodium chloride

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2021  Publisher: Syri Limited, Unit 4, Bradfield Road, Ruislip, Middlesex, HA4 0NU, UK Trading as: Thame Laboratories, Unit 4, Bradfield Road, Ruislip, Middlesex, HA4 0NU, UK OR Trading as: SyriMed, Unit 4, Bradfield Road, ...

5.1. Pharmacodynamic properties

ATC Code: A12CA01 Other mineral supplements, sodium

Mode of action: Sodium chloride is the principle salt involved in maintaining the osmotic tension of blood and tissues. Changes in osmotic tension influence the movement of fluids and diffusion of salts in cellular tissue.

Syrisal 1 mmol/ml oral solution provides a source of sodium (in the form of sodium chloride) where a deficiency exists.

5.2. Pharmacokinetic properties

Absorption

Sodium chloride is readily absorbed from the gastro-intestinal tract.

Distribution

It is present in all body fluids but specially in the extracellular fluid.

Biotransformation

Sodium chloride is not significantly metabolised.

Elimination

Excess sodium is mainly excreted by the kidney, and small amounts are list in the faeces and sweat.

Linearity/non-linearity

Osmotic balance is maintained by excretion of surplus amounts in the urine.

5.3. Preclinical safety data

Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, toxicity to reproduction and development.

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