Source: Web Search Revision Year: 1997
Wytensin is indicated in the treatment of hypertension. It may be employed alone or in combination with a thiazide diuretic.
Dosage with Wytensin should be individualized. A starting dose of 4 mg twice a day is recommended, whether Wytensin is used alone or with a thiazide diuretic. Dosage may be increased in increments of 4 to 8 mg per day every one to two weeks, depending on the patient’s response. The maximum dose studied to date has been 32 mg twice daily, but doses as high as this are rarely needed.
Accidental ingestion of Wytensin caused hypotension, somnolence, lethargy, irritability, miosis, and bradycardia in two pediatric patients aged one and three years. Gastric lavage and administration of pressor substances, fluids, and oral activated charcoal resulted in complete and uneventful recovery within 12 hours in both patients.
Since experience with accidental overdosage is limited, the suggested treatment is mainly supportive while the drug is being eliminated from the body and until the patient is no longer symptomatic. Vital signs and fluid balance should be carefully monitored. An adequate airway should be maintained and, if indicated, assisted respiration instituted. There are no data available on the dialyzability of Wytensin.
Keep tightly closed.
Store at room temperature, approximately 25ºC (77ºF).
Protect from light.
Dispense in a light-resistant, tight container.
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