Aclarubicin

Also known as: Aclacinomycin A

Description

Aclarubicin belongs to the anthracycline family and is less cardiotoxic than doxorubicin and daunorubicin. The mechanism of action of aclarubicin is based on its capacity to insert its trisaccharide chain into the minor DNA groove: poison of topoisomerase I, inhibitor of topoisomerase II, eviction of histones from nucleosomes, but also inhibitor of the 20S proteasome.

Medicine classification

ATC Code
Title
Class
Aclarubicin
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01D Cytotoxic antibiotics and related substances → L01DB Anthracyclines and related substances

2D Molecule Structure

2D representation of molecule

Unique Ingredient Identifier (UNII)

74KXF8I502 - ACLARUBICIN

CAS Registry Number

57576-44-0 - aclarubicin

SNOMED-CT

391713006 - Aclarubicin (substance)