Aclarubicin Other names: Aclacinomycin A

Chemical formula: C₄₂H₅₃NO₁₅  Molecular mass: 811.878 g/mol  PubChem compound: 451415

Active ingredient description

Aclarubicin is an anthracycline antibiotic produced by Streptomyces galilaeus and also has potent antineoplastic activity. It is less cardiotoxic than doxorubicin and daunorubicin. The mechanism of action of aclarubicin is based on its capacity to insert its trisaccharide chain into the minor DNA groove: poison of topoisomerase I, inhibitor of topoisomerase II, eviction of histones from nucleosomes, but also inhibitor of the 20S proteasome.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01DB04 Aclarubicin L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01D Cytotoxic antibiotics and related substances → L01DB Anthracyclines and related substances
Discover more medicines within L01DB04

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 57576-44-0
DrugBank Drug: DB11617
KEGG Drug: D02756
PubChem Compound: 451415
RxNorm Ingredient: 239
SNOMED-CT Concept: 391713006
Aclarubicin (substance)
UNII Identifier: 74KXF8I502


Aclarubicin is an active ingredient of these brands:

Japan (JP)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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