Aclarubicin Other names: Aclacinomycin A
Chemical formula: C₄₂H₅₃NO₁₅ Molecular mass: 811.878 g/mol PubChem compound: 451415
Active ingredient description
Aclarubicin is an anthracycline antibiotic produced by Streptomyces galilaeus and also has potent antineoplastic activity. It is less cardiotoxic than doxorubicin and daunorubicin. The mechanism of action of aclarubicin is based on its capacity to insert its trisaccharide chain into the minor DNA groove: poison of topoisomerase I, inhibitor of topoisomerase II, eviction of histones from nucleosomes, but also inhibitor of the 20S proteasome.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| L01DB04 | Aclarubicin | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01D Cytotoxic antibiotics and related substances → L01DB Anthracyclines and related substances |
Medicines
Aclarubicin is an active ingredient of these brands:
Japan (JP)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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