Aclarubicin

Also known as: Aclacinomycin A

Active ingredient description

Aclarubicin belongs to the anthracycline family and is less cardiotoxic than doxorubicin and daunorubicin. The mechanism of action of aclarubicin is based on its capacity to insert its trisaccharide chain into the minor DNA groove: poison of topoisomerase I, inhibitor of topoisomerase II, eviction of histones from nucleosomes, but also inhibitor of the 20S proteasome.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Aclarubicin
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01D Cytotoxic antibiotics and related substances → L01DB Anthracyclines and related substances
Discover more medicines within L01DB04

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

74KXF8I502 - ACLARUBICIN

CAS registry number

57576-44-0 - aclarubicin

SNOMED-CT

391713006 - Aclarubicin (substance)