Chemical formula: C₃₂H₃₅ClFN₇O₂  Molecular mass: 604.119 g/mol  PubChem compound: 138611145

Therapeutic indications

Adagrasib is indicated for:

Advanced non-small cell lung cancer with KRAS G12C mutation

Population group: only adults (18 years old or older)

Adagrasib as monotherapy is indicated for the treatment of adult patients with advanced non-small cell lung cancer (NSCLC) with KRAS G12C mutation and disease progression after at least one prior systemic therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):


Adagrasib is contraindicated in the following cases:





Concomitant use of CYP3A substrates with a narrow therapeutic index

at least one of
CYP3A4 substrates
Cytochrome P-450 CYP3A5 substrates
and additionally Narrow Therapeutic Index Drugs (NTI)

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