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Afamelanotide

Description

Afamelanotide is a synthetic tridecapeptide and a structural analogue of α-melanocyte stimulating hormone (α-MSH). Afamelanotide is a melanocortin receptor agonist and binds predominantly to the melanocortin-1 receptor (MC1R). Afamelanotide is thought to mimic the endogenous compound’s pharmacological activity by activating the synthesis of eumelanin mediated by the MC1R receptor. Eumelanin contributes to photoprotection through different mechanisms.

ATC Classification

Code
Title
Category
D02BB02
Afamelanotide
D Dermatologicals → D02 Emollients and protectives → D02B Protectives against UV-radiation → D02BB Protectives against UV-radiation for systemic use

Trade names

Trade name
Countries

Austria Netherlands United States

Product Monographs

Monograph
Type
Country
SCENESSE Implant
MPI, EU: SmPC