Afamelanotide

Active ingredient description

Afamelanotide is a synthetic tridecapeptide and a structural analogue of α-melanocyte stimulating hormone (α-MSH). Afamelanotide is a melanocortin receptor agonist and binds predominantly to the melanocortin-1 receptor (MC1R). Afamelanotide is thought to mimic the endogenous compound’s pharmacological activity by activating the synthesis of eumelanin mediated by the MC1R receptor. Eumelanin contributes to photoprotection through different mechanisms.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Afamelanotide
D Dermatologicals → D02 Emollients and protectives → D02B Protectives against UV-radiation → D02BB Protectives against UV-radiation for systemic use
Discover more medicines within D02BB02

Medicines

Afamelanotide is the active ingredient of these drugs:

Drug
Countries

Austria Ireland Lithuania Netherlands United Kingdom

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of product characteristics (SPC)

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

QW68W3J66U - AFAMELANOTIDE

SNOMED-CT

819968004 - Afamelanotide (substance)