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Afatinib

Description

Afatinib is a potent and selective, irreversible ErbB Family Blocker. Afatinib covalently binds to and irreversibly blocks signalling from all homo- and heterodimers formed by the ErbB family members EGFR (ErbB1), HER2 (ErbB2), ErbB3 and ErbB4.

ATC Classification

Code
Title
Category
L01EB03
Afatinib
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EB Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors

Trade names

Trade name
Countries
GILOTRIF

United States

GIOTRIF

Australia Austria Canada Cyprus Netherlands

Product Monographs

Monograph
Type
Country
GIOTRIF Film-coated tablets
MPI, EU: SmPC

2D Molecule Structure

Unique Ingredient Identifier (UNII)

41UD74L59M - AFATINIB

CAS Registry Number

439081-18-2 - afatinib

SNOMED-CT

703579002 - Afatinib (substance)

 
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