Agalsidase alfa

Active ingredient description

Agalsidase alfa catalyses the hydrolysis of Gb3, cleaving a terminal galactose residue from the molecule. Treatment with the enzyme has been shown to reduce accumulation of Gb3 in many cell types including endothelial and parenchymal cells. Agalsidase alfa has been produced in a human cell line to provide for a human glycosylation profile that can influence uptake by mannose-6-phosphate receptors on the surface of target cells.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
A16AB03
Agalsidase alfa
A Alimentary tract and metabolism → A16 Other alimentary tract and metabolism products → A16A Other alimentary tract and metabolism products → A16AB Enzymes
Discover more medicines within A16AB03

Medicines

Agalsidase alfa is the active ingredient of these drugs:

Drug
Countries
REPLAGAL

Austria Brazil Canada Finland France

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
REPLAGAL Concentrate solution for infusion
Summary of Product Characteristics (SPC)

3D molecular structure

3D representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

2HLC17MX9G - AGALSIDASE ALFA

CAS registry number

104138-64-9 - agalsidase beta

SNOMED-CT

424905009 - Agalsidase alfa (substance)

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