Agomelatine

Chemical formula: C₁₅H₁₇NO₂  Molecular mass: 243.301 g/mol  PubChem compound: 82148

Active ingredient description

Agomelatine is a melatonergic agonist (MT1 and MT2 receptors) and 5-HT2C antagonist. In humans, agomelatine has positive phase shifting properties; it induces a phase advance of sleep, body temperature decline and melatonin onset.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N06AX22 Agomelatine N Nervous system → N06 Psychoanaleptics → N06A Antidepressants → N06AX Other antidepressants
Discover more medicines within N06AX22

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
VALDOXAN Film-coated tablets European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 138112-76-2
DrugBank Drug: DB06594
KEGG Drug: D02578
PubChem Compound: 82148
SNOMED-CT Concept: 698012009
Agomelatine (substance)
UNII Identifier: 137R1N49AD
AGOMELATINE

Medicines

Agomelatine is an active ingredient of these brands:

Austria (AT)

Brazil (BR)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Italy (IT)

Lithuania (LT)

Malta (MT)

Netherlands (NL)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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