Alectinib

Active ingredient description

Alectinib is a highly selective and potent ALK and RET tyrosine kinase inhibitor. In preclinical studies, inhibition of ALK tyrosine kinase activity led to blockage of downstream signalling pathways including STAT 3 and PI3K/AKT and induction of tumour cell death (apoptosis).

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01ED Anaplastic lymphoma kinase (ALK) inhibitors
Discover more medicines within L01ED03

Medicines

Alectinib is the active ingredient of these drugs:

Drug
Countries

Australia Austria Brazil Cyprus Ecuador

Canada

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)

Structural formula

Graphic representation of the active ingredient's molecular structure

Molecular mass: 482.617 g/mol

External identifiers

CAS Substance: 1256580-46-7
DrugBank Drug: DB11363
KEGG Drug: D10542
RxNorm Ingredient: 1727455
SNOMED-CT Concept: 716039000
Alectinib (substance)
UNII Identifier: LIJ4CT1Z3Y
ALECTINIB