Alectinib

Active ingredient description

Alectinib is a highly selective and potent ALK and RET tyrosine kinase inhibitor. In preclinical studies, inhibition of ALK tyrosine kinase activity led to blockage of downstream signalling pathways including STAT 3 and PI3K/AKT and induction of tumour cell death (apoptosis).

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
L01ED03
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01ED Anaplastic lymphoma kinase (ALK) inhibitors
Discover more medicines within L01ED03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
ALECENSA Hard capsule
Summary of Product Characteristics (SPC)

Medicines

Alectinib is the active ingredient of these drugs:

Drug
Countries
ALECENSA

Australia Austria Brazil Cyprus Ecuador

ALECENSARO

Canada

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₃₀H₃₄N₄O₂
Molecular mass: 482.617 g/mol

External identifiers

CAS Substance: 1256580-46-7
DrugBank Drug: DB11363
KEGG Drug: D10542
PubChem Compound: 49806720
RxNorm Ingredient: 1727455
SNOMED-CT Concept: 716039000
Alectinib (substance)
UNII Identifier: LIJ4CT1Z3Y
ALECTINIB
 
Next: Usage >