Alpelisib

Active ingredient description

Alpelisib is an inhibitor of phosphatidylinositol-3-kinase (PI3K) with inhibitory activity predominantly against PI3Kα. Gain-of-function mutations in the gene encoding the catalytic α-subunit of PI3K (PIK3CA) lead to activation of PI3Kα and Akt-signaling, cellular transformation and the generation of tumors in in vitro and in vivo models.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EM Phosphatidylinositol-3-kinase (Pi3K) inhibitors
Discover more medicines within L01EM03

Medicines

$substanceName is the active ingredient of these drugs:

Drug
Countries

Austria Brazil Canada Estonia Finland

South Africa

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Structured Product Labeling (SPL/PLR)
US

Structural formula

Graphic representation of the active ingredient's molecular structure

Molecular mass: 441.47 g/mol

External identifiers

CAS Substance: 1217486-61-7
DrugBank Drug: DB12015
RxNorm Ingredient: 2169285
SNOMED-CT Concept: 788050002
Alpelisib (substance)
UNII Identifier: 08W5N2C97Q
ALPELISIB