Alpelisib

Active ingredient description

Alpelisib is an inhibitor of phosphatidylinositol-3-kinase (PI3K) with inhibitory activity predominantly against PI3Kα. Gain-of-function mutations in the gene encoding the catalytic α-subunit of PI3K (PIK3CA) lead to activation of PI3Kα and Akt-signaling, cellular transformation and the generation of tumors in in vitro and in vivo models.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
L01EM03
Alpelisib
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EM Phosphatidylinositol-3-kinase (Pi3K) inhibitors
Discover more medicines within L01EM03

Medicines

Alpelisib is the active ingredient of these drugs:

Drug
Countries
PIQRAY

Austria Brazil Canada France Hong Kong

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
PIQRAY Tablet
Structured product labeling (SPL/PLR)
US

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

08W5N2C97Q - ALPELISIB

SNOMED-CT

788050002 - Alpelisib (substance)

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