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Alpelisib

Description

Alpelisib is an inhibitor of phosphatidylinositol-3-kinase (PI3K) with inhibitory activity predominantly against PI3Kα. Gain-of-function mutations in the gene encoding the catalytic α-subunit of PI3K (PIK3CA) lead to activation of PI3Kα and Akt-signaling, cellular transformation and the generation of tumors in in vitro and in vivo models.

ATC Classification

Code
Title
Category
L01EM03
Alpelisib
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EM Phosphatidylinositol-3-kinase (Pi3K) inhibitors

Trade names

Trade name
Countries

Austria Canada France Netherlands United Kingdom

Product Monographs

Monograph
Type
Country
PIQRAY Tablet
MPI, US: SPL/PLR
US