Alteplase

Also known as: Tissue-type plasminogen activator precursor tPA t-PA t-plasminogen activator

Active ingredient description

Alteplase is a recombinant human tissue-type plasminogen activator, a glycoprotein, which activates plasminogen directly to plasmin. Once bound to fibrin, it is activated, inducing the conversion of plasminogen to plasmin leading to the dissolution of the fibrin clot.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
B01AD02
Alteplase
B Blood and blood forming organs → B01 Antithrombotic agents → B01A Antithrombotic agents → B01AD Enzymes
Discover more medicines within B01AD02
S01XA13
Alteplase
S Sensory organs → S01 Ophthalmologicals → S01X Other ophthalmologicals → S01XA Other ophthalmologicals
Discover more medicines within S01XA13

Medicines

Alteplase is the active ingredient of these drugs:

Drug
Countries
ACTILYSE

Austria Brazil Cyprus Ecuador Estonia

ACTIVASE RT-PA

Canada

CATHFLO

Canada United States

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
ACTILYSE Powder and solvent for solution
Summary of Product Characteristics (SPC)
UK
CATHFLO ACTIVASE Powder for solution for injection
Structured Product Labeling (SPL)
US

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 105857-23-6
DrugBank Drug: DB00009
KEGG Drug: D02837
SNOMED-CT Concept: 387152000
Alteplase (substance)
UNII Identifier: 1RXS4UE564
ALTEPLASE
 
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