Alteplase Other names: Tissue-type plasminogen activator precursor tPA t-PA t-plasminogen activator

Active ingredient description

Alteplase is a recombinant human tissue-type plasminogen activator, a glycoprotein, which activates plasminogen directly to plasmin. Once bound to fibrin, it is activated, inducing the conversion of plasminogen to plasmin leading to the dissolution of the fibrin clot.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
B01AD02 Alteplase B Blood and blood forming organs → B01 Antithrombotic agents → B01A Antithrombotic agents → B01AD Enzymes
Discover more medicines within B01AD02
S01XA13 Alteplase S Sensory organs → S01 Ophthalmologicals → S01X Other ophthalmologicals → S01XA Other ophthalmologicals
Discover more medicines within S01XA13

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ACTILYSE Powder and solvent for solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
CATHFLO ACTIVASE Powder for solution for injection FDA, National Drug Code (US) MPI, US: SPL/Old

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 105857-23-6
DrugBank Drug: DB00009
KEGG Drug: D02837
SNOMED-CT Concept: 387152000
Alteplase (substance)
UNII Identifier: 1RXS4UE564
ALTEPLASE

Medicines

Alteplase is an active ingredient of these brands:

United States (US)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

Lithuania (LT)

Malta (MT)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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