Also known as: Tissue-type plasminogen activator precursor tPA t-PA t-plasminogen activator
Alteplase is a recombinant human tissue-type plasminogen activator, a glycoprotein, which activates plasminogen directly to plasmin. Once bound to fibrin, it is activated, inducing the conversion of plasminogen to plasmin leading to the dissolution of the fibrin clot.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
Alteplase is the active ingredient of these drugs:
Austria Brazil Cyprus Ecuador Estonia
Canada United States
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):