Also known as: Tissue-type plasminogen activator precursor tPA t-PA t-plasminogen activator
Alteplase is a recombinant human tissue-type plasminogen activator, a glycoprotein, which activates plasminogen directly to plasmin. Once bound to fibrin, it is activated, inducing the conversion of plasminogen to plasmin leading to the dissolution of the fibrin clot.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
Alteplase is the active ingredient of these drugs:
Austria Brazil Cyprus Finland France
Canada United States
Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):