Also known as: 1-aminoadamantane Amantadine Amantadine hydrochloride
Brand names: GOCOVRI OSMOLEX ER
Amantadine has been shown to be a low affinity antagonist at the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. Overactivity of glutamatergic neurotransmission has been implicated in the generation of parkinsonian symptoms. In addition, amantadine specifically inhibits the replication of influenza A viruses at low concentrations.