Amantadine Other names: 1-aminoadamantane Amantadine Amantadine hydrochloride

Chemical formula: C₁₀H₁₇N  Molecular mass: 151.249 g/mol  PubChem compound: 2130

Active ingredient description

Amantadine has been shown to be a low affinity antagonist at the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. Overactivity of glutamatergic neurotransmission has been implicated in the generation of parkinsonian symptoms. In addition, amantadine specifically inhibits the replication of influenza A viruses at low concentrations.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N04BB01 Amantadine N Nervous system → N04 Anti-parkinson drugs → N04B Dopaminergic agents → N04BB Adamantane derivatives
Discover more medicines within N04BB01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
TRILASYM Oral solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 665-66-7
CAS Substance: 768-94-5
DrugBank Drug: DB00915
PubChem Compound: 2130
RxNorm Ingredient: 620
SNOMED-CT Concept: 372763006
Amantadine (substance)
UNII Identifier: BF4C9Z1J53


Amantadine is an active ingredient of these brands:

United States (US)

Albania (AL)

Australia (AU)

Austria (AT)

Brazil (BR)

Croatia (HR)

Estonia (EE)

France (FR)

Hong Kong (HK)

Israel (IL)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Tunisia (TN)

Turkey (TR)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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