Amantadine

Also known as: 1-aminoadamantane Amantadine Amantadine hydrochloride

Active ingredient description

Amantadine has been shown to be a low affinity antagonist at the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. Overactivity of glutamatergic neurotransmission has been implicated in the generation of parkinsonian symptoms. In addition, amantadine specifically inhibits the replication of influenza A viruses at low concentrations.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
N04BB01
Amantadine
N Nervous system → N04 Anti-parkinson drugs → N04B Dopaminergic agents → N04BB Adamantane derivatives
Discover more medicines within N04BB01

Medicines

Amantadine is the active ingredient of these drugs:

Drug
Countries
AMANDIN

Hong Kong

AMANTEX

Tunisia

ENZIL

Hong Kong

GOCOVRI

United States

MANTADIX

France

MANTIDAN

Brazil

OSMOLEX ER

United States

PK-MERZ

Austria Hong Kong Lithuania

SYMMETREL

Australia Hong Kong Netherlands Singapore

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
TRILASYM Oral solution
Summary of product characteristics (SPC)
UK

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

BF4C9Z1J53 - AMANTADINE

CAS registry number

665-66-7 - 1-Adamantanamine, hydrochloride

768-94-5 - amantadine

SNOMED-CT

372763006 - Amantadine (substance)

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