Amantadine Other names: 1-aminoadamantane Amantadine Amantadine hydrochloride
Chemical formula: C₁₀H₁₇N Molecular mass: 151.249 g/mol PubChem compound: 2130
Active ingredient description
Amantadine has been shown to be a low affinity antagonist at the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. Overactivity of glutamatergic neurotransmission has been implicated in the generation of parkinsonian symptoms. In addition, amantadine specifically inhibits the replication of influenza A viruses at low concentrations.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| N04BB01 | Amantadine | N Nervous system → N04 Anti-parkinson drugs → N04B Dopaminergic agents → N04BB Adamantane derivatives |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| TRILASYM Oral solution | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) |
Medicines
Amantadine is an active ingredient of these brands:
Albania (AL)
Australia (AU)
Austria (AT)
Brazil (BR)
Croatia (HR)
Estonia (EE)
France (FR)
Hong Kong (HK)
Israel (IL)
Japan (JP)
Lithuania (LT)
Malta (MT)Mexico (MX)
Netherlands (NL)
New Zealand (NZ)
Poland (PL)Romania (RO)
Singapore (SG)
South Africa (ZA)Tunisia (TN)Turkey (TR)
United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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