Amantadine

Also known as: 1-aminoadamantane Amantadine Amantadine hydrochloride

Active ingredient description

Amantadine has been shown to be a low affinity antagonist at the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. Overactivity of glutamatergic neurotransmission has been implicated in the generation of parkinsonian symptoms. In addition, amantadine specifically inhibits the replication of influenza A viruses at low concentrations.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
N04BB01
Amantadine
N Nervous system → N04 Anti-parkinson drugs → N04B Dopaminergic agents → N04BB Adamantane derivatives
Discover more medicines within N04BB01

Medicines

Amantadine is the active ingredient of these drugs:

Drug
Countries
AMANDIN

Hong Kong

AMANTEX

Tunisia

AMANTIX

Poland

ENZIL

Hong Kong

GOCOVRI

United States

MANTADIX

France

MANTIDAN

Brazil

OSMOLEX ER

United States

PK-MERZ

Austria Hong Kong Lithuania

SYMMETREL

Australia Hong Kong Netherlands New Zealand Singapore

VIREGYT-K

Poland

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
TRILASYM Oral solution
Summary of Product Characteristics (SPC)
UK

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

BF4C9Z1J53 - AMANTADINE

CAS registry number

665-66-7 - 1-Adamantanamine, hydrochloride

768-94-5 - amantadine

SNOMED-CT

372763006 - Amantadine (substance)

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