Therapeutic indications

Amiodarone is indicated for:


Irrespective of gender only Adults (18 years old or older)

  • Treatment of severe rhythm disorders not responding to other therapies or when other treatments cannot be used.
  • Tachyarrhythmias associated with Wolff-Parkinson-White Syndrome.
  • Atrial flutter and fibrillation when other drugs cannot be used.
  • All types of tachyarrhythmias of paroxysmal nature including: supraventricular, nodal and ventricular tachycardias, ventricular fibrillation: when other drugs cannot be used.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 200-600 mg daily

Treatment 2: Intravenous - 300mg over 20 minutes to 2 hours, followed by 900mg over 24 hours


Active ingredient Amiodarone is contraindicated in the following cases:

Drugs inducing Torsade de Pointes

The combination of amiodarone with drugs which may induce torsades de pointes is contra-indicated.


Amiodarone is excreted into the breast milk in significant quantities and breast-feeding is contra-indicated.


There are insufficient data on the use of amiodarone during pregnancy in humans to judge any possible toxicity.

However, in view of its effect on the foetal thyroid gland, amiodarone is contraindicated during pregnancy, except in exceptional circumstances.

If, because of the long half-life of amiodarone, discontinuation of the drug is considered prior to planned conception, the real risk of reoccurrence of life threatening arrhythmias should be weighed against the possible hazard for the foetus.

Thyroid dysfunction

Amiodarone is contraindicated in thyroid dysfunction. Thyroid function tests should be performed in all patients prior to therapy.

Sinus bradycardia, sino-atrial heart block

Amiodarone is contraindicated in sinus bradycardia and sino-atrial heart block.