Chemical formula: C₁₆H₁₄Br₂N₆O₄S  Molecular mass: 545.914 g/mol  PubChem compound: 25099191

Therapeutic indications

Aprocitentan is indicated for:


Population group: only adults (18 years old or older)

Aprocitentan, in combination with other antihypertensive drugs, is indicated for the treatment of hypertension, to lower blood pressure (BP) in adult patients who are not adequately controlled on other drugs. Lowering BP reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes. There are no controlled trials demonstrating reduction of risk of these events with aprocitentan.

For this indication, competent medicine agencies globally authorize below treatments (click for details):


Aprocitentan is contraindicated in the following cases:



Elevated aminotransferases, moderate to severe hepatic impairment

at least one of
Elevated liver enzymes level
Hepatic failure stage III
Hepatic failure stage IV

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