Artemether and Lumefantrine

Therapeutic indications

Artemether and Lumefantrine is indicated for:

Plasmodium falciparum malaria

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Artemether/lumefantrine combination is indicated for the treatment of acute uncomplicated Plasmodium falciparum malaria in adults, children and infants of 5 kg and above.

Consideration should be given to official guidance regarding the appropriate use of antimalarial agents.

For this indication, competent medicine agencies globally authorize below treatments (click for details):


Artemether and Lumefantrine is contraindicated in the following cases:

Severe malaria according to WHO definition

Complicated malaria

CYP2D6 substrates

CYP2D6 substrates

Family history of sudden death or of congenital prolongation of the QTc interval, conditions prolonging the QTc interval

at least one of
Family history of sudden death
Family history of congenital long QT syndrome
Risk factors that increase the risk of QT prolongation

Drugs that are known to prolong the QTc interval

Drugs prolonging QT interval

History of symptomatic cardiac arrythmias, bradycardia, congestive cardiac failure

at least one of
Congestive heart failure due to left ventricular systolic dysfunction

Disturbances of electrolyte balance

Disorder of electrolytes

Strong inducers of CYP3A4

Strong potency CYP3A4 inducers

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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