Chemical formula: C₂₀H₁₈ClF₂N₅O₃ Molecular mass: 449.84 g/mol PubChem compound: 72165228
Asciminib is a potent inhibitor of ABL/BCR::ABL1 tyrosine kinase. Asciminib inhibits the ABL1 kinase activity of the BCR::ABL1 fusion protein by specifically targeting the ABL myristoyl pocket.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
|L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EA BCR-ABL tyrosine kinase inhibitors
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
|SCEMBLIX Film-coated tablet
|European Medicines Agency (EU)
|MPI, EU: SmPC
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