Asciminib

Chemical formula: C₂₀H₁₈ClF₂N₅O₃  Molecular mass: 449.84 g/mol  PubChem compound: 72165228

Active ingredient description

Asciminib is a potent inhibitor of ABL/BCR::ABL1 tyrosine kinase. Asciminib inhibits the ABL1 kinase activity of the BCR::ABL1 fusion protein by specifically targeting the ABL myristoyl pocket.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01EA06 L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EA BCR-ABL tyrosine kinase inhibitors
Discover more medicines within L01EA06

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
SCEMBLIX Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 1492952-76-7
DrugBank Drug: DB12597
KEGG Drug: D11403
PubChem Compound: 72165228
RxNorm Ingredient: 2584304
UNII Identifier: L1F3R18W77
ASCIMINIB

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