Ataluren

Chemical formula: C₁₅H₉FN₂O₃  Molecular mass: 284.242 g/mol  PubChem compound: 11219835

Active ingredient description

A nonsense mutation in DNA results in a premature stop codon within an mRNA. This premature stop codon in the mRNA causes disease by terminating translation before a full-length protein is generated. Ataluren enables ribosomal readthrough of mRNA containing such a premature stop codon, resulting in production of a full-length protein.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
M09AX03
M Musculo-skeletal system → M09 Other drugs for disorders of the musculo-skeletal system → M09A Other drugs for disorders of the musculo-skeletal system → M09AX Other drugs for disorders of the musculo-skeletal system
Discover more medicines within M09AX03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Information Source
Document Type
 
TRANSLARNA Granules for oral suspension
European Medicines Agency (EU)
MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 775304-57-9
DrugBank Drug: DB05016
KEGG Drug: D09323
PubChem Compound: 11219835
SNOMED-CT Concept: 718843009
Ataluren (substance)
UNII Identifier: K16AME9I3V
ATALUREN

Medicines

Ataluren is an active ingredient of these brands:

Austria (AT)

Brazil (BR)

Estonia (EE)

Finland (FI)

France (FR)

Ireland (IE)

Lithuania (LT)

Netherlands (NL)

Poland (PL)

Romania (RO)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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