Atezolizumab
Brand names: TECENTRIQ
Therapeutic Indications
Atezolizumab is indicated for:
Small cell carcinoma of lung
Irrespective of gender only Adults (18 years old or older)
Atezolizumab, in combination with carboplatin and etoposide, is indicated for the first-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC).
For this indication, the medical literature mentions below treatments (click for details):
Treatment 1: Intravenous - 1.2 gr once every 3 weeks
Urothelial carcinoma
Irrespective of gender only Adults (18 years old or older)
Atezolizumab as monotherapy is indicated for the treatment of adult patients with locally advanced or metastatic urothelial carcinoma (UC):
- after prior platinum-containing chemotherapy, or
- who are considered cisplatin ineligible, and whose tumours have a PD-L1 expression ≥5%.
For this indication, the medical literature mentions below treatments (click for details):
Treatment 1: Intravenous - 1.2 gr once every 3 weeks
Nonsquamous nonsmall cell neoplasm of lung
Irrespective of gender only Adults (18 years old or older)
Atezolizumab, in combination with bevacizumab, paclitaxel and carboplatin, is indicated for the first-line treatment of adult patients with metastatic non-squamous non-small cell lung cancer (NSCLC). In patients with EGFR mutant or ALK-positive NSCLC, atezolizumab, in combination with bevacizumab, paclitaxel and carboplatin, is indicated only after failure of appropriate targeted therapies.
Atezolizumab as monotherapy is indicated for the treatment of adult patients with locally advanced or metastatic NSCLC after prior chemotherapy. Patients with EGFR mutant or ALK-positive NSCLC should also have received targeted therapies before receiving atezolizumab.
Atezolizumab, in combination with nab-paclitaxel and carboplatin, is indicated for the first-line treatment of adult patients with metastatic non-squamous NSCLC who do not have EGFR mutant or ALK-positive NSCLC.
For this indication, the medical literature mentions below treatments (click for details):
Treatment 1: Intravenous - 1.2 gr once every 3 weeks
Contraindications
Active ingredient Atezolizumab is contraindicated in the following cases: