Atosiban C₄₃H₆₇N₁₁O₁₂S₂

Therapeutic indications

Atosiban is indicated for:

Pre-term birth

Population group: women, only adults (18 - 65 years old)

Atosiban is indicated to delay imminent pre-term birth in pregnant women with:

regular uterine contractions of at least 30 seconds duration at a rate of ≥4 per 30 minutes
a cervical dilation of 1 to 3 cm (0-3 for nulliparas) and effacement of ≥50%
age ≥18 years
a gestational age from 24 until 33 completed weeks
a normal fetal heart rate.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

6.75-270 mg in 3 doses

Contraindications

Atosiban is contraindicated in the following cases:

Premature rupture of the membranes >30 weeks of gestation

Preterm premature rupture of membranes (disorder)

Abnormal foetal heart rate

Abnormal fetal heart rate (finding)

Antepartum uterine haemorrhage requiring immediate delivery

Antepartum hemorrhage (disorder)

Eclampsia, severe pre-eclampsia requiring delivery

at least one of

Eclampsia (disorder)

Severe pre-eclampsia (disorder)

Intrauterine foetal death

Fetal death (event)

Suspected intrauterine infection

Infection of uterus (disorder)

Placenta praevia

Placenta previa (disorder)

Abruptio placenta

Placental abruption (disorder)

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