Atrasentan

Chemical formula: C₂₉H₃₈N₂O₆  Molecular mass: 510.273 g/mol  PubChem compound: 159594

Active ingredient description

Atrasentan is an ETA receptor antagonist (Ki = 0.034 nM) with >1800-fold selectivity for the ETA receptor compared to the endothelin type B receptor (Ki = 63.3 nM). Endothelin (ET)-1 is thought to contribute to the pathogenesis of IgAN via the ETAR.

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 VANRAFIA Film-coated tablet MPI, US: SPL/PLR FDA, National Drug Code (US)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 195733-43-8
DrugBank Drug: DB06199
KEGG Drug: D03009
PubChem Compound: 159594
UNII Identifier: V6D7VK2215
ATRASENTAN

Medicines

Atrasentan is an active ingredient of these brands:

United States (US)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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