Auranofin

Active ingredient description

The main mechanism of action of auranofin is through the inhibition of reduction/oxidation (redox) enzymes such as thioredoxin reductase (TrxR). The thiol ligand contained in auranofin has a high affinity for thiol and selenol groups, to which it forms stable, and irreversible, adducts 14. Redox enzymes such as TrxR are essential to many cellular processes, particularly in maintaining the intracellular levels of reactive oxygen species (ROS).

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Auranofin
M Musculo-skeletal system → M01 Antiinflammatory and antirheumatic products → M01C Specific antirheumatic agents → M01CB Gold preparations
Discover more medicines within M01CB03

Medicines

Auranofin is the active ingredient of these drugs:

Drug
Countries

Australia Canada South Africa United States

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

3H04W2810V - AURANOFIN

CAS registry number

34031-32-8 - auranofin

SNOMED-CT

387100001 - Auranofin (substance)