Auranofin

Description

The main mechanism of action of auranofin is through the inhibition of reduction/oxidation (redox) enzymes such as thioredoxin reductase (TrxR). The thiol ligand contained in auranofin has a high affinity for thiol and selenol groups, to which it forms stable, and irreversible, adducts 14. Redox enzymes such as TrxR are essential to many cellular processes, particularly in maintaining the intracellular levels of reactive oxygen species (ROS).

Medicine classification

ATC Code
Title
Class
Auranofin
M Musculo-skeletal system → M01 Antiinflammatory and antirheumatic products → M01C Specific antirheumatic agents → M01CB Gold preparations

Medicines

Drug
Countries

Australia Canada United States

2D Molecule Structure

2D representation of molecule

3D Molecule Structure

3D representation of molecule

Unique Ingredient Identifier (UNII)

3H04W2810V - AURANOFIN

CAS Registry Number

34031-32-8 - auranofin

SNOMED-CT

387100001 - Auranofin (substance)