Auranofin
Chemical formula: C₂₀H₃₄AuO₉PS Molecular mass: 678.484 g/mol PubChem compound: 24199313
Active ingredient description
Auranofin is an orally available compound, used to treat rheumatoid arthritis, with anti-inflammatory activities. The main mechanism of action of auranofin is through the inhibition of reduction/oxidation (redox) enzymes such as thioredoxin reductase (TrxR). The thiol ligand contained in auranofin has a high affinity for thiol and selenol groups, to which it forms stable, and irreversible, adducts. Redox enzymes such as TrxR are essential to many cellular processes, particularly in maintaining the intracellular levels of reactive oxygen species (ROS).
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| M01CB03 | Auranofin | M Musculo-skeletal system → M01 Antiinflammatory and antirheumatic products → M01C Specific antirheumatic agents → M01CB Gold preparations |
Medicines
Auranofin is an active ingredient of these brands:
Australia (AU)Canada (CA)South Africa (ZA)United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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