Avacincaptad pegol

Active ingredient description

Avacincaptad pegol is an RNA aptamer, a PEGylated oligonucleotide that binds to and inhibits complement protein C5. By inhibiting C5, avacincaptad pegol may prevent its cleavage to C5a and C5b thus decreasing membrane attack complex (MAC) formation.

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
IZERVAY Intravitreal solution FDA, National Drug Code (US) MPI, US: SPL/PLR

External identifiers

DrugBank Drug: DB15165
KEGG Drug: D11748
RxNorm Ingredient: 2645108
UNII Identifier: TT0V5JLG5B


Avacincaptad pegol is an active ingredient of these brands:

United States (US)


Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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