Avacincaptad pegol is an RNA aptamer, a PEGylated oligonucleotide that binds to and inhibits complement protein C5. By inhibiting C5, avacincaptad pegol may prevent its cleavage to C5a and C5b thus decreasing membrane attack complex (MAC) formation.
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
|IZERVAY Intravitreal solution
|FDA, National Drug Code (US)
|MPI, US: SPL/PLR
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