Avalglucosidase alfa

Active ingredient description

Avalglucosidase alfa is a recombinant human acid α-glucosidase (rhGAA) that provides an exogenous source of GAA. Binding to M6P receptors on the cell surface has been shown to occur via carbohydrate groups on the GAA molecule, after which it is internalised and transported into lysosomes, where it undergoes proteolytic cleavage that results in increased enzymatic activity to degrade glycogen.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
A Alimentary tract and metabolism → A16 Other alimentary tract and metabolism products → A16A Other alimentary tract and metabolism products → A16AB Enzymes
Discover more medicines within A16AB22

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)

External identifiers

CAS Substance: 1802558-87-7
DrugBank Drug: DB16099
KEGG Drug: D11744
RxNorm Ingredient: 2565814
UNII Identifier: EO144CP0X9
AVALGLUCOSIDASE ALFA

Medicines

Avalglucosidase alfa is an active ingredient of these brands:

Austria (AT)

Japan (JP)

Lithuania (LT)

Romania (RO)

While we strive to include the brand names of medicines across all countries, our index remains incomplete. Therefore, it is possible that this medicine may also be marketed under different names in other countries.