Chemical formula: C₂₉H₃₄Cl₂N₆O₃S₂  Molecular mass: 649.65 g/mol  PubChem compound: 9852519

Active ingredient description

Avatrombopag is an orally active, small molecule thrombopoietin (TPO) receptor agonist that stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells resulting in increased production of platelets. Avatrombopag does not compete with TPO for binding to the TPO receptor and has an additive effect with TPO on platelet production.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
B02BX08 B Blood and blood forming organs → B02 Antihemorrhagics → B02B Vitamin K and other hemostatics → B02BX Other systemic hemostatics
Discover more medicines within B02BX08

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
DOPTELET Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC
DOPTELET Film-coated tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 570406-98-3
DrugBank Drug: DB11995
PubChem Compound: 9852519
RxNorm Ingredient: 2045726
SNOMED-CT Concept: 770717002
Avatrombopag (substance)
UNII Identifier: 3H8GSZ4SQL


Avatrombopag is an active ingredient of these brands:

United States (US)

Austria (AT)

Croatia (HR)

Estonia (EE)

Finland (FI)

Ireland (IE)

Lithuania (LT)

Poland (PL)

Romania (RO)

Spain (ES)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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