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Baclofen

Therapeutic Indications

Baclofen is indicated for:

Spasticity of voluntary muscle

Irrespective of gender only Adults (18 years old or older)

Baclofen is indicated for the relief of spasticity of voluntary muscle resulting from such disorders as multiple sclerosis, other spinal lesions e.g. tumours of the spinal cord, syringomyelia, motor neurone disease, transverse myelitis, traumatic partial section of the cord.

Baclofen is also indicated in adults and children for the relief of spasticity of voluntary muscle arising from e.g. cerebrovascular accidents, cerebral palsy, meningitis, traumatic head injury.

Patient selection is important when initiating baclofen therapy; it is likely to be of most benefit in patients whose spasticity constitutes a handicap to activities and/or physiotherapy. Treatment should not be commenced until the spastic state has become stabilized.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 15-100 mg in 3 divided doses daily

Treatment 2: Intraspinal - 25-1400 ug

Spasticity of voluntary muscle

Irrespective of gender only Minors (0 - 18 years old)

Baclofen is indicated in patients 0 to <18 years for the symptomatic treatment of spasticity of cerebral origin, especially where due to infantile cerebral palsy, as well as following cerebrovascular accidents or in the presence of neoplastic or degenerative brain disease.

Baclofen is also indicated for the symptomatic treatment of muscle spasms occurring in spinal cord diseases of infectious, degenerative, traumatic, neoplastic, or unknown origin such as multiple sclerosis, spastic spinal paralysis, amyotrophic lateral sclerosis, syringomyelia, transverse myelitis, traumatic paraplegia or paraparesis, and compression of the spinal cord.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 0.3-2.0 mg/kg in 2-4 divided doses daily

Contraindications

Active ingredient Baclofen is contraindicated in the following cases:

Peptic ulceration

No gender/age discrimination

Hypersensitivity to baclofen

No gender/age discrimination