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Bedaquiline

Description

Bedaquiline is a diarylquinoline. Bedaquiline specifically inhibits mycobacterial ATP (adenosine 5'-triphosphate) synthase, an essential enzyme for the generation of energy in Mycobacterium tuberculosis. The inhibition of ATP synthase leads to bactericidal effects for both replicating and non-replicating tubercle bacilli.

ATC Classification

Code
Title
Category
J04AK05
Bedaquiline
J Antiinfectives for systemic use → J04 Antimycobacterials → J04A Drugs for treatment of tuberculosis → J04AK Other drugs for treatment of tuberculosis

Trade names

Trade name
Countries

Austria Cyprus Netherlands United States

Product Monographs

Monograph
Type
Country
SIRTURO Tablet
MPI, EU: SmPC