Belantamab mafodotin

Active ingredient description

Belantamab mafodotin is a humanised IgG1Îș monoclonal antibody conjugated with a cytotoxic agent, maleimidocaproyl monomethyl auristatin F (mcMMAF). Belantamab mafodotin binds to cell surface BCMA and is rapidly internalised. Apoptosis induced by belantamab mafodotin is accompanied by markers of immunogenic cell death, which may contribute to an adaptive immune response to tumour cells.

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
BLENREP Powder for concentrate for solution for infusion European Medicines Agency (EU) MPI, EU: SmPC
BLENREP Powder for solution for injection FDA, National Drug Code (US) MPI, US: SPL/PLR

External identifiers

CAS Substance: 2050232-20-5
DrugBank Drug: DB15719
RxNorm Ingredient: 2387834
UNII Identifier: DB1041CXDG


Belantamab mafodotin is an active ingredient of these brands:

United States (US)

Austria (AT)

Croatia (HR)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Lithuania (LT)

Poland (PL)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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