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Belatacept

Description

Belatacept, a modified form of CTLA4-Ig, binds CD80 and CD86 more avidly than the parent CTLA4-Ig molecule from which it is derived. This increased avidity provides a level of immunosuppression that is necessary for preventing immune-mediated allograft failure and dysfunction. Belatacept blocks CD28 mediated co-stimulation of T cells inhibiting their activation.

ATC Classification

Code
Title
Category
L04AA28
Belatacept
L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AA Selective immunosuppressants

Trade names

Trade name
Countries

Austria Netherlands United States

Product Monographs

Monograph
Type
Country
NULOJIX Powder for concentrate for solution for infusion
MPI, EU: SmPC