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Belimumab

Description

Belimumab is a human IgG1λ monoclonal antibody specific for soluble human B Lymphocyte Stimulator protein (BLyS, also referred to as BAFF and TNFSF13B). Belimumab blocks the binding of soluble BLyS, a B cell survival factor, to its receptors on B cells. Belimumab by binding BLyS inhibits the survival of B cells, including autoreactive B cells, and reduces the differentiation of B cells into immunoglobulin-producing plasma cells.

ATC Classification

Code
Title
Category
L04AA26
Belimumab
L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AA Selective immunosuppressants

Trade names

Trade name
Countries

Austria Canada Cyprus France Netherlands

Product Monographs

Monograph
Type
Country
BENLYSTA Powder for concentrate for solution for infusion
MPI, EU: SmPC
BENLYSTA Solution for injection
MPI, EU: SmPC