Chemical formula: C₂₆H₂₄N₆O₂  Molecular mass: 452.196 g/mol  PubChem compound: 11950170

Active ingredient description

Belumosudil is a serine/threonine kinase inhibitor indicated for the treatment of chronic graft-versus-host disease (chronic GVHD). Specifically, it is an inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2; ROCK-II). Belumosudil binds to and inhibits the serine/threonine kinase activity of ROCK2. This inhibits ROCK2-mediated signaling pathways which play major roles in pro- and anti-inflammatory immune cell responses.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L04AA48 L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AA Selective immunosuppressants
Discover more medicines within L04AA48

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
REZUROCK Tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 911417-87-3
DrugBank Drug: DB16703
KEGG Drug: D11815
PubChem Compound: 11950170
RxNorm Ingredient: 2564025
SNOMED-CT Concept: 1163566003
Belumosudil (substance)
UNII Identifier: 834YJF89WO


Belumosudil is an active ingredient of these brands:

United States (US)

Canada (CA)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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