Benzocaine

Chemical formula: C₉H₁₁NO₂ Molecular mass: 165.189 g/mol PubChem compound: 2337

Active ingredient description

Benzocaine is a local anaesthetic of the ester type, acting to produce reversible loss of sensation by preventing or diminishing the generation and transmission of sensory nerve impulses near the site of application. Depolarisation of the neuronal membrane and ion exchange are reversibly inhibited.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group		Classification
C05AD03	Benzocaine	C Cardiovascular system → C05 Vasoprotectives → C05A Agents for treatment of hemorrhoids and anal fissures for topical use → C05AD Local anesthetics
Discover more medicines within C05AD03
D04AB04	Benzocaine	D Dermatologicals → D04 Antipruritics, incl. antihistamines, anesthetics, etc. → D04A Antipruritics, incl. antihistamines, anesthetics, etc. → D04AB Anesthetics for topical use
Discover more medicines within D04AB04
N01BA05	Benzocaine	N Nervous system → N01 Anesthetics → N01B Anesthetics, local → N01BA Esters of aminobenzoic acid
Discover more medicines within N01BA05
R02AD01	Benzocaine	R Respiratory system → R02 Throat preparations → R02A Throat preparations → R02AD Anesthetics, local
Discover more medicines within R02AD01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document	Type	Information Source
ORAJEL Dental gel	MPI, EU: SmPC	Medicines & Healthcare Products Regulatory Agency (GB)
LANACANE Creme	MPI, EU: SmPC	Medicines & Healthcare Products Regulatory Agency (GB)
ULTRA CHLORASEPTIC ANAESTHETIC THROAT SPRAY 0.71% Oromucosal Spray	MPI, EU: SmPC	Medicines & Healthcare Products Regulatory Agency (GB)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 94-09-7
DrugBank Drug: DB01086
KEGG Drug: D00552
PubChem Compound: 2337
RxNorm Ingredient: 1399
SNOMED-CT Concept: 273960006: Benzocaine (substance)
SNOMED-CT Concept: 387357002: Benzocaine (substance)
UNII Identifier: U3RSY48JW5: BENZOCAINE

Medicines

Benzocaine is an active ingredient of these brands:

Austria (AT)

ANAESTHERIT
(combination) DORITHRICIN
(combination) HERPOSICC
(combination) INSECTICUM

Brazil (BR)

BENZOTOP
(combination) ANDOLBA
(combination) GINGILONE
(combination) MALVONA
(combination) NEOPIRIDIN
(combination) PREDMICIN
(combination) SANILIN

Canada (CA)

(combination) AURALGAN
(combination) ONE TOUCH
(combination) ZAP

Cyprus (CY)

(combination) FLAVACO WITH HYDROCORTISONE

Ecuador (EC)

HURRICAINE
OTICAINA
(combination) ANESTENKA
(combination) BUCAGEL
(combination) BUCAGEL NF
(combination) BUCOSEPT
(combination) NORAVER P
(combination) ORACOL
(combination) OTODYNE
(combination) OTOTRICINA
(combination) RUBEXAL
(combination) SINAFTA

Estonia (EE)

(combination) NEOCONES
(combination) SEPTOLETE PLUS
(combination) TONCILS

Finland (FI)

(combination) BAFUCIN
(combination) TONCILS

Hong Kong (HK)

HURRICAINE
(combination) DEZOCAINE
(combination) GARYDOL
(combination) LINALON
(combination) TYROCAINE

Ireland (IE)

BURNEZE
(combination) WASP-EZE

Israel (IL)

HURRICAINE
(combination) OTOMYCIN

Japan (JP)

(combination) HELMITIN S

Lithuania (LT)

(combination) ALMAGEL A
(combination) HEXORALETTEN N
(combination) MENOVAZINAS
(combination) NEOCONES
(combination) SEPTOLETE PLUS

Malta (MT)

TOPIGEL

Mexico (MX)

GRANEODIN B

New Zealand (NZ)

(combination) AURALGAN
(combination) CEPACAINE
(combination) ZAP

Poland (PL)

(combination) DORICOMB
(combination) DORITRI
(combination) SEBIDIN INTENSIVE
(combination) SEPTOLETE PLUS
(combination) VARIDERM

Romania (RO)

(combination) HEMORZON
(combination) HEXORALETTEN N

Singapore (SG)

FREEZ-EEZ
HURRICAINE
TOPICALE
(combination) DORITHRICIN
(combination) HORF

South Africa (ZA)

ORAJEL
(combination) CEPACAINE
(combination) OROCHLOR

Spain (ES)

DENTISPRAY
HURRICAINE
NANI PREDENTAL
NORMOBUCAL
(combination) ANESTEFARIN
(combination) ANGILEPTOL
(combination) ANGINOCOM
(combination) APOGAR
(combination) BUCOMETASANA
(combination) DERATIN COMPLEX
(combination) FARBUCAL
(combination) FARINGENILO
(combination) FARINGESIC
(combination) HEMOAL
(combination) INTERDOL
(combination) LIZIPAINA
(combination) MASTIOL

Turkey (TR)

(combination) ANZIBEL

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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