Chemical formula: C₃₀H₂₆F₄N₆O Molecular mass: 562.573 g/mol
Berotralstat is an inhibitor of plasma kallikrein. In patients with hereditary angioedema (HAE) due to C1-INH deficiency or dysfunction, normal regulation of plasma kallikrein activity is impaired, which leads to uncontrolled increases in plasma kallikrein activity and bradykinin release, resulting in HAE attacks consisting of swelling (angioedema).
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| B06AC06 | B Blood and blood forming organs → B06 Other hematological agents → B06A Other hematological agents → B06AC Drugs used in hereditary angioedema | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ORLADEYO Hard capsule | European Medicines Agency (EU) | MPI, EU: SmPC |
Berotralstat is an active ingredient of these brands:
Estonia (EE)
Ireland (IE)
Israel (IL)
Japan (JP)
Lithuania (LT)
Poland (PL)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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