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Brand names: BESIVANCE

Pharmacodynamic Properties

Besifloxacin is a fluoroquinolone antibacterial.

Pharmacokinetic Properties

Plasma concentrations of besifloxacin were measured in adult patients with suspected bacterial conjunctivitis who received besifloxacin bilaterally three times a day (16 doses total). Following the first and last dose, the maximum plasma besifloxacin concentration in each patient was less than 1.3 ng/mL. The mean besifloxacin Cmax was 0.37 ng/mL on day 1 and 0.43 ng/mL on day 6. The average elimination half-life of besifloxacin in plasma following multiple dosing was estimated to be 7 hours.

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