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Bexarotene

Description

Bexarotene is a synthetic compound that exerts its biological action through selective binding and activation of the three RXRs: α, β, and γ. Once activated, these receptors function as transcription factors that regulate processes such as cellular differentiation and proliferation, apoptosis, and insulin sensitisation. The exact mechanism of action of bexarotene in the treatment of cutaneous T-cell lymphoma (CTCL) is unknown.

ATC Classification

Code
Title
Category
L01XF03
Bexarotene
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XF Retinoids for cancer treatment

Trade names

Trade name
Countries

Austria Netherlands United States

Product Monographs

Monograph
Type
Country
TARGRETIN Soft capsule
MPI, EU: SmPC