Bicalutamide

Chemical formula: C₁₈H₁₄F₄N₂O₄S  Molecular mass: 430.373 g/mol  PubChem compound: 2375

Interactions

Bicalutamide interacts in the following cases:

CYP3A4 substrates

Bicalutamide has been shown to inhibit cytochrome P450 (CYP3A4), as such, caution should be exercised when co-administered with drugs metabolised predominantly by CYP 3A4.

Hepatic impairment

Bicalutamide is extensively metabolised in the liver. Data suggest that its elimination may be slower in subjects with severe hepatic impairment and this could lead to increased accumulation of bicalutamide. Therefore, bicalutamide 150 mg should be used with caution in patients with moderate to severe hepatic impairment.

Periodic liver function testing should be considered due to the possibility of hepatic changes. The majority of changes are expected to occur within the first 6 months of bicalutamide therapy.

Severe hepatic changes and hepatic failure have been observed rarely with bicalutamide 150 mg, and fatal outcomes have been reported. Bicalutamide 150 mg therapy should be discontinued if changes are severe.

Coumarin anticoagulants

In vitro studies have shown that bicalutamide can displace the coumarin anticoagulant, warfarin, from its protein binding sites. There have been reports of increased effect of warfarin and other coumarin anticoagulants when co-administered with bicalutamide. It is therefore recommended that if bicalutamide 150 mg is administered in patients who are concomitantly receiving coumarin anticoagulants, PT/INR should be closely monitored and adjustments of anticoagulant dose considered.

Fertility

Reversible impairment of male fertility has been observed in animal studies. A period of subfertility or infertility should be assumed in man.

Ciclosporin, calcium channel blockers

In vitro studies have shown that R-bicalutamide is an inhibitor of CYP 3A4, with lesser inhibitory effects on CYP 2C9, 2C19 and 2D6 activity. Although clinical studies using antipyrine as a marker of cytochrome P450 (CYP) activity showed no evidence of a drug interaction potential with bicalutamide, mean midazolam exposure (AUC) was increased by up to 80% after co-administration of bicalutamide for 28 days. For drugs with a narrow therapeutic index such an increase could be of relevance. As such, concomitant use of terfenadine, astemizole and cisapride is contraindicated and caution should be exercised with the co-administration of bicalutamide with compounds such as ciclosporin and calcium channel blockers. Dosage reduction may be required for these drugs particularly if there is evidence of enhanced or adverse drug effect. For ciclosporin, it is recommended that plasma concentrations and clinical condition are closely monitored following initiation or cessation of bicalutamide therapy.

Cimetidine, ketoconazole

Caution should be exercised when prescribing bicalutamide with other drugs which may inhibit drug oxidation e.g. cimetidine and ketoconazole. In theory, this could result in increased plasma concentrations of bicalutamide which theoretically could lead to an increase in side effects.

Prolonged QT interval, medicinal products that might prolong the QT interval

Androgen deprivation therapy may prolong the QT interval. In patients with a history of or risk factors for QT prolongation and in patients receiving concomitant medicinal products that might prolong the QT interval, physicians should assess the benefit risk ratio including the potential for Torsade de pointes prior to initiating bicalutamide.

Pregnancy

Bicalutamide is contraindicated in females and must not be given to pregnant women.

Nursing mothers

Bicalutamide is contraindicated during breast-feeding.

Carcinogenesis, mutagenesis and fertility

Fertility

Reversible impairment of male fertility has been observed in animal studies. A period of subfertility or infertility should be assumed in man.

Effects on ability to drive and use machines

Bicalutamide is unlikely to impair the ability of patients to drive or operate machinery. However, it should be noted that occasionally somnolence may occur. Any affected patients should exercise caution.

Adverse reactions


In this section, undesirable effects are defined as follows: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to ≤1/100); rare (≥1/10,000 to ≤1/1,000); very rare (≤1/10,000); not known (cannot be estimated from the available data).

Frequency of Adverse Reactions:

Blood and the lymphatic system disorders

Common: Anaemia

Immune system disorders

Uncommon: Hypersensitivity, angioedema and urticaria

Metabolism and nutrition disorders

Common: Decreased appetite

Psychiatric disorders

Common: Decreased libido, Depression

Nervous system disorders

Common: Dizziness, Somnolence

Cardiac disorders

Not known: QT prolongation

Vascular disorders

Common: Hot flush

Respiratory, thoracic and mediastinal disorders

Uncommon: Interstitial lung diseasee (fatal outcomes have been reported).

Gastrointestinal disorders

Common: Abdominal pain, Constipation, Dyspepsia, Flatulence, Nausea

Hepato-biliary disorders

Common: Hepatotoxicity, jaundice, hypertransaminasaemiaa

Rare: Hepatic failured (fatal outcomes have been reported).

Skin and subcutaneous tissue disorders

Very common: Rash

Common: Alopecia, Hirsutism/hair re-growth, Dry skinc, Pruritus

Rare: Photosensitivity reaction

Renal and urinary disorders

Common: Haematuria

Reproductive system and breast disorders

Very common: Gynaecomastia and breast tendernessb

Common: Erectile dysfunction

General disorders and administration site conditions

Very common: Asthenia

Common: Chest pain, Oedema

Investigations

Common: Weight increased

a Hepatic changes are rarely severe and were frequently transient, resolving or improving with continued therapy or following cessation of therapy.
b The majority of patients receiving bicalutamide 150 mg as monotherapy experience gynaecomastia and/or breast pain. In studies these symptoms were considered to be severe in up to 5% of the patients. Gynaecomastia may not resolve spontaneously following cessation of therapy, particularly after prolonged treatment.
c Due to the coding conventions used in the EPC studies, adverse events of ‘dry skin’ were coded under the COSTART term of ‘rash’. No separate frequency descriptor can therefore be determined for the 150 mg bicalutamide dose however the same frequency as the 50 mg dose is assumed.
d Listed as an adverse drug reaction following review of post-marketed data. Frequency has been determined from the incidence of reported adverse events of hepatic failure in patients receiving treatment in the open-label bicalutamide arm of the 150 mg EPC studies.
e Listed as an adverse drug reaction following review of post-marketed data. Frequency has been determined from the incidence of reported adverse events of interstitial pneumonia in the randomised treatment period of the 150 mg EPC studies.

Increased PT/INR: Accounts of coumarin anticoagulants interacting with bicalutamide have been reported in post-marketing surveillance.

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