Chemical formula: C₆₀H₈₆N₁₆O₁₃ Molecular mass: 1,239.447 g/mol
Buserelin is indicated for:
Population group: men, only adults (18 years old or older)
Buserelin is indicated For the treatment of advanced hormone dependent prostatic carcinoma (stage C or stage D according to the classification of Murphy et al, in Cancer 45, p1889-95, 1980) in which suppression of testosterone is indicated; however, not after bilateral orchiectomy (no further reduction of testosterone level by buserelin to be expected).
Buserelin acts by blockade and subsequent down-regulation of pituitary LHRH receptor synthesis. Gonadotropin release is consequently inhibited. As a result of this inhibition there is reduced stimulation of testosterone secretion and serum testosterone levels fall to castration range. Before inhibition occurs there is a brief stimulatory phase during which testosterone levels may rise.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Buserelin is contraindicated in the following cases:
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