Chemical formula: C₂₀H₂₁CaN₇O₇ Molecular mass: 473.446 g/mol PubChem compound: 6006
Calcium folinate is an active metabolite of folinic acid and essential coenzyme for nucleic acid synthesis in cytotoxic therapy. Calcium folinate is frequently used to diminish the toxicity and counteract the action of folate antagonists, such as methotrexate.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| V03AF03 | Calcium folinate | V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AF Detoxifying agents for antineoplastic treatment |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| CALCIUM FOLINATE Tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| CALCIUM FOLINATE Solution for injection / infusion | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Calcium folinate is an active ingredient of these brands:
Australia (AU)
Brazil (BR)
Cyprus (CY)
Ecuador (EC)
Estonia (EE)
Finland (FI)
France (FR)
Germany (DE)
Hong Kong (HK)
Israel (IL)
Japan (JP)
Malta (MT)
Netherlands (NL)
New Zealand (NZ)
Romania (RO)
Singapore (SG)
South Africa (ZA)Spain (ES)
Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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