Calcium

Chemical formula: Ca  Molecular mass: 40.078 g/mol  PubChem compound: 5460341

Pharmacodynamic properties

An adequate intake of calcium is of importance during growth, pregnancy and breastfeeding.

Pharmacokinetic properties

Absorption

The amount of calcium absorbed through the gastrointestinal tract is approximately 30% of the swallowed dose.

Distribution and biotransformation

99% of the calcium in the body is concentrated in the hard structure of bones and teeth. The remaining 1% is present in the intra- and extracellular fluids. About 50% of the total blood-calcium content is in the physiologically active ionised form with approximately 10% being complexed to citrate, phosphate or other anions, the remaining 40% being bound to proteins, principally albumin.

Excretion and elimination

Calcium is eliminated through faeces, urine and sweat. Renal excretion depends on glomerular filtration and calcium tubular reabsorption.

Preclinical safety data

There is no information.

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