Capsaicin

Chemical formula: C₁₈H₂₇NO₃  Molecular mass: 305.412 g/mol  PubChem compound: 1548943

Active ingredient description

Capsaicin, or 6-nonenamide, N-[(4-hydroxy-3-methoxyphenyl) methyl]-8-methyl, (6E), is a highly selective agonist for the transient receptor potential vanilloid 1 receptor (TRPV1). The initial effect of capsaicin is the activation of TRPV1-expressing cutaneous nociceptors, which results in pungency and erythema due to the release of vasoactive neuropeptides.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
M02AB01 Capsaicin M Musculo-skeletal system → M02 Topical products for joint and muscular pain → M02A Topical products for joint and muscular pain → M02AB Capsaicin and similar agents
Discover more medicines within M02AB01
N01BX04 Capsaicin N Nervous system → N01 Anesthetics → N01B Anesthetics, local → N01BX Other local anesthetics
Discover more medicines within N01BX04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
QUTENZA Cutaneous patch European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 404-86-4
DrugBank Drug: DB06774
KEGG Drug: D00250
PubChem Compound: 1548943
RxNorm Ingredient: 1992
SNOMED-CT Concept: 95995002
Capsaicin (substance)
UNII Identifier: S07O44R1ZM
CAPSAICIN

Medicines

Capsaicin is an active ingredient of these brands:

Austria (AT)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

  • (combination) RAKOOL as Capsicum extract

Lithuania (LT)

Malta (MT)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

South Africa (ZA)

Spain (ES)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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