Chemical formula: C₄₅H₆₉N₁₁O₁₂S Molecular mass: 988.161 g/mol PubChem compound: 16681432
Carbetocin interacts in the following cases:
Since it has been found that prostaglandins potentiate the effect of oxytocin, it is expected that this can also occur with carbetocin. Therefore, it is not recommended that prostaglandins and carbetocin be used together. If they are concomitantly administered, the patient should be carefully monitored.
During combination with ergot-alkaloids, such as methylergometrine, oxytocin and carbetocin may enhance the blood pressure enhancing effect of these agents. If oxytocin or methylergometrine are administered after carbetocin there may be a risk of cumulative exposure.
Some inhalation-anesthetics, such as halothane and cyclopropane may enhance the hypotensive effect and weaken the effect of carbetocin on the uterus. Arrhythmias have been reported for oxytocin during concomitant use.
Since carbetocin is closely related in structure to oxytocin, the occurrence of interactions known to be associated with oxytocin cannot be excluded:
Severe hypertension has been reported when oxytocin was given 3 to 4 hours following prophylactic administration of a vasoconstrictor in conjunction with caudal-block anaesthesia.
During combination with ergot-alkaloids, such as methylergometrine, oxytocin and carbetocin may enhance the blood pressure enhancing effect of these agents. If oxytocin or methylergometrine are administered after carbetocin there may be a risk of cumulative exposure.
Since it has been found that prostaglandins potentiate the effect of oxytocin, it is expected that this can also occur with carbetocin. Therefore, it is not recommended that prostaglandins and carbetocin be used together. If they are concomitantly administered, the patient should be carefully monitored.
Animal studies have shown carbetocin to possess some antidiuretic activity (vasopressin activity: <0.025 IU/vial) and therefore the possibility of hyponatraemia cannot be excluded, particularly in patients also receiving large volumes of intravenous fluids. The early signs of drowsiness, listlessness and headache should be recognised to prevent convulsions and coma.
In general, carbetocin should be used cautiously in the presence of migraine, asthma and cardiovascular disease or any state in which a rapid addition to extracellular water may produce hazard for an already overburdened system. The decision of administering carbetocin can be made by the physician after carefully weighing the potential benefit carbetocin may provide in these particular cases.
Carbetocin is contraindicated during pregnancy and must not be used for the induction of labour.
No significant effects on milk let-down have been reported during clinical trials. Small amounts of carbetocin have been shown to pass from plasma into breast milk of nursing women. The small amounts transferred into colostrum or breast milk after a single injection of carbetocin, and subsequently ingested by the infant are assumed to be degraded by enzymes in the gut.
Breast-feeding does not need to be restricted after the use of carbetocin.
Not relevant.
The adverse events observed with carbetocin during the clinical trials were of the same type and frequency as the adverse events observed with oxytocin.
Intravenous administration* – Tabulated summary of adverse reactions:
Very common ≥1/10
Common ≥1/100 and <1/10
Not known (cannot be estimated from the available data)
Common: Anaemia
Very common: Headache, tremor
Common: Dizziness
Not known: Tachycardia, bradycardia***, arrhythmia***, myocardial ischaemia***, and QT prolongation***
Very common: Hypotension, flushing
Common: Chest pain, dyspnoea
Very common: Nausea, abdominal pain
Common: Metallic taste, vomiting
Very common: Pruritus
Common: Back pain
Very common: Feeling of warmth
Common: Chills, pain
* Based on studies in caesarean section
*** Reported with oxytocin (closely related in structure to carbetocin)
In the clinical trials sweating was reported as sporadic cases.
Intramuscular administration** – Tabulated summary of adverse reactions:
Uncommon ≥1/1,000 and <1/100
Rare ≥1/10,000 and <1/1,000
Not known (cannot be estimated from the available data)
Uncommon: Anaemia
Uncommon: Headache, dizziness
Rare: Tremor
Uncommon: Tachycardia
Not known: Bradycardia***, arrhythmia***, myocardial ischaemia***, and QT prolongation***
Uncommon: Hypotension
Rare: Flushing
Uncommon: Chest pain
Rare: Dyspnoea
Uncommon: Nausea, abdominal pain, vomiting
Rare: Pruritus
Uncommon: Back pain, muscular weakness
Rare: Urinary retention
Uncommon: Chills, pyrexia, pain
** Based on studies in vaginal delivery
*** Reported with oxytocin (closely related in structure to carbetocin)
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