Carvedilol

Chemical formula: C₂₄H₂₆N₂O₄  Molecular mass: 406.474 g/mol  PubChem compound: 2585

Therapeutic indications

Carvedilol is indicated for:

Chronic stable angina pectoris

Population group: only adults (18 years old or older)

Stable angina

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Essential hypertension

Population group: only adults (18 years old or older)

Essential hypertension

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Mild-to-severe chronic heart failure of ischemic or cardiomyopathic origin

Population group: only adults (18 years old or older)

Carvedilol tablets are indicated for the treatment of mild-to-severe chronic heart failure of ischemic or cardiomyopathic origin, usually in addition to diuretics, ACE inhibitors, and digitalis, to increase survival and, also, to reduce the risk of hospitalization.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Left ventricular dysfunction following myocardial infarction

Population group: only adults (18 years old or older)

Carvedilol is indicated to reduce cardiovascular mortality in clinically stable patients who have survived the acute phase of a myocardial infarction and have a left ventricular ejection fraction of less than or equal to 40% (with or without symptomatic heart failure).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Carvedilol is contraindicated in the following cases:

Heart failure NYHA Class IV

Heart failure New York Heart Assosiation Class IV

Chronic obstructive pulmonary disease

Chronic obstructive lung disease

Clinically significant hepatic dysfunction

Hepatic insufficiency

History of bronchospasm or asthma

at least one of
Airway hyperreactivity
H/O: asthma
Bronchospasm

Second degree atrioventricular heart block

Second degree atrioventricular block

Third degree atrioventricular heart block

Complete atrioventricular block

Severe bradycardia

Bradycardia

Sick sinus syndrome

at least one of
Sick sinus syndrome
Sinoatrial block

Cardiogenic shock

Cardiogenic shock

Severe hypotension

Hypotension

Prinzmetal's angina

Prinzmetal angina

Untreated phaeochromocytoma

Phaeochromocytoma

Metabolic acidosis

Metabolic acidosis

Severe peripheral arterial circulatory disturbances

Peripheral arterial occlusive disease

Verapamil, diltiazem

at least one of
Verapamil
Diltiazem

Bronchial asthma

Airway hyperreactivity

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