Cerliponase alfa

Active ingredient description

Cerliponase alfa is a recombinant form of human tripeptidyl peptidase-1 (rhTPP1). Cerliponase alfa is a proteolytic inactive proenzyme (zymogen) that is activated in the lysosome. The glycosylation profile of cerliponase alfa results in consistent cellular uptake and lysosomal targeting for activation.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A16AB17 A Alimentary tract and metabolism → A16 Other alimentary tract and metabolism products → A16A Other alimentary tract and metabolism products → A16AB Enzymes
Discover more medicines within A16AB17

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
BRINEURA Solution for infusion European Medicines Agency (EU) MPI, EU: SmPC

External identifiers

CAS Substance: 151662-36-1
DrugBank Drug: DB13173
KEGG Drug: D10813
RxNorm Ingredient: 1922436
SNOMED-CT Concept: 734039005
Cerliponase alfa (substance)
UNII Identifier: X8R2D92QP1
CERLIPONASE ALFA

Medicines

Cerliponase alfa is an active ingredient of these brands:

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

Estonia (EE)

Ireland (IE)

Japan (JP)

Lithuania (LT)

Netherlands (NL)

Poland (PL)

Romania (RO)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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