Cetuximab

Therapeutic indications

Cetuximab is indicated for:

Colorectal cancer EGFR + (epidermal growth factor receptor positive)

Population group: only adults (18 years old or older)

Cetuximab is indicated for the treatment of patients with epidermal growth factor receptor (EGFR)-expressing, RAS wild-type metastatic colorectal cancer:

  • in combination with irinotecan-based chemotherapy,
  • in first-line in combination with FOLFOX,
  • as a single agent in patients who have failed oxaliplatin- and irinotecan-based therapy and who are intolerant to irinotecan.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Squamous cell cancer of the head and neck

Population group: only adults (18 years old or older)

Cetuximab is indicated for the treatment of patients with squamous cell cancer of the head and neck:

  • in combination with radiation therapy for locally advanced disease,
  • in combination with platinum-based chemotherapy for recurrent and/or metastatic disease.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Cetuximab is contraindicated in the following cases:

Mutant RAS gene

at least one of
Oncogene protein H-RAS
Oncogene protein K-RAS
Oncogene protein N-RAS
Oncogene protein P21, RAS

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