Chloroprocaine Other names: Nesacaine

Chemical formula: C₁₃H₁₉ClN₂O₂  Molecular mass: 270.755 g/mol  PubChem compound: 8612

Active ingredient description

Chloroprocaine is procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. Chloroprocaine, blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential. Chloroprocaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N01BA04 Chloroprocaine N Nervous system → N01 Anesthetics → N01B Anesthetics, local → N01BA Esters of aminobenzoic acid
Discover more medicines within N01BA04
S01HA08 S Sensory organs → S01 Ophthalmologicals → S01H Local anesthetics → S01HA Local anesthetics
Discover more medicines within S01HA08

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
AMPRES 10 mg/ml Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
AMPRES 20 mg/ml Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 133-16-4
DrugBank Drug: DB01161
KEGG Drug: D07678
PubChem Compound: 8612
RxNorm Ingredient: 20859
SNOMED-CT Concept: 71668006
Chloroprocaine (substance)
UNII Identifier: 5YVB0POT2H
CHLOROPROCAINE

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